TABLE 2.
Volume of distribution and clearance of AVI with intermittent infusiona
| Arm | Volume of distribution (liters) | Clearance (liter/h) | Time at ≥4 mg/liter (h) | AUCss (mg . h/liter) |
|---|---|---|---|---|
| ≥4 mg/liter for 4 of 8 h | 3.06 | 3.29 | 4.58 | 456 |
| ≥4 mg/liter for 5 of 8 h | 4.88 | 3.58 | 5.48 | 419 |
| ≥4 mg/liter for 6 of 8 h | 6.83 | 4.09 | 5.88 | 367 |
| ≥4 mg/liter for 7 of 8 h | 8.66 | 4.25 | 6.47 | 353 |
| ≥4 mg/liter for 8 of 8 h | 11.1 | 3.90 | 7.96 | 382 |
a
These values allow calculation of the time at an AVI concentration of ≥4 mg/liter, as well as the AVI AUC at steady state. Note that, as the time above the critical value of 4 mg/liter decreased, the rate of bacterial kill decreased. The AUC value seen in all arms was substantially greater than the AUC seen in experiment 1 for resistance suppression (AUC of 89.3 mg · h/liter).