TABLE 2.
Overall hrHPV and type-specific concordance between Alinity m and cobas assessed on all samples with valid HPV results included in the VALGENT-3 panel (n = 1,584)
HPV typeb | Value (no.) by test result |
Concordance (%) | Kappaa | |||||
---|---|---|---|---|---|---|---|---|
Alinity m+ | cobas+ | Alinity m+/cobas+ | Alinity m+/cobas− | Alinity m−/cobas+ | Alinity m−/cobas− | |||
14 hr types | 349 | 345 | 328 | 21 | 17 | 1,218 | 97.60 | 0.9299 |
HPV-16 | 116 | 114 | 112 | 4 | 2 | 1,466 | 99.62 | 0.9719 |
HPV-18 | 34 | 35 | 32 | 2 | 3 | 1,547 | 99.68 | 0.9259 |
HPV-16/18 | 145 | 145 | 139 | 6 | 6 | 1,449 | 99.31 | 0.9581 |
Kappa legend (adapted from Landis and Koch [36]) for levels of agreement: 1.00 ≥ κ > 0.80, excellent; 0.80 ≥ κ > 0.60, good; 0.60 ≥ κ > 0.40, moderate; 0.40 ≥ κ > 0.20, fair; 0.20 ≥ κ > 0.00, poor.
HPV-16, -18, and -16/18 indicate that particular HPV types are present as a single or multiple infections.