TABLE 4.
Overall hrHPV and type-specific concordance between Alinity m and Linear Array assessed on all samples with valid HPV results included in the VALGENT-3 panel (n = 1,593)
| HPV typeb | Value (no.) by test result |
Concordance (%) | Kappaa | |||||
|---|---|---|---|---|---|---|---|---|
| Alinity m+ | LA+ | Alinity m+/LA+ | Alinity m+/LA− | Alinity m−/LA+ | Alinity m−/LA− | |||
| 14 hr types | 349 | 332 | 332 | 17 | 7 | 1,237 | 98.49 | 0.9555 |
| HPV-16 | 116 | 113 | 112 | 4 | 1 | 1,476 | 99.81 | 0.9859 |
| HPV-18 | 34 | 34 | 31 | 3 | 2 | 1,556 | 99.62 | 0.9098 |
| HPV-16/18 | 145 | 141 | 138 | 7 | 3 | 1,452 | 99.44 | 0.9653 |
| HPV-45 | 13 | 14 | 11 | 2 | 3 | 1,577 | 99.69 | 0.8132 |
| HPV group A | 138 | 137 | 128 | 10 | 9 | 1,446 | 98.81 | 0.9244 |
| HPV group B | 122 | 122 | 113 | 9 | 9 | 1,462 | 98.87 | 0.9201 |
a
Kappa legend (adapted from Landis and Koch [36]) for levels of agreement: 1.00 ≥ κ > 0.80, excellent; 0.80 ≥ κ > 0.60, good; 0.60 ≥ κ > 0.40, moderate; 0.40 ≥ κ > 0.20, fair; 0.20 ≥ κ > 0.00, poor.
b
HPV-16, -18, and -16/18 indicate that particular HPV types are present as a single or multiple infections. HPV group A includes HPV-31, -33, -52, and -58; HPV group B includes HPV-35, -39, -51, -56, -59, -66, and -68.