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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Clin Pharmacol Ther. 2021 Mar 14;110(2):409–423. doi: 10.1002/cpt.2195

Figure 2. Antidepressant + precipitant drug associations with unintentional traumatic injury.

Figure 2.

Panel A depicts associations for antidepressants with 5-hydroxytryptamine receptor antagonist properties (nefazodone [N], trazodone [T], vortioxetine [V]). Panel B depicts associations for selective serotonin reuptake inhibitors (citalopram [C], escitalopram [E], fluoxetine [F], fluvoxamine [Fl], paroxetine [P], sertraline [S], vilazodone [Vi]) and serotonin-norepinephrine reuptake inhibitors (desvenlafaxine [D], duloxetine [Du], levomilnacipran [L], venlafaxine [Ve]). Panel C depicts associations for other antidepressants (amitriptyline [A], amoxapine [Am], bupropion [B], clomipramine [Cl], desipramine [De], doxepin [Do], imipramine [I], maprotiline [M], mirtazapine [Mi], nortriptyline [No], protriptyline [Pr], trimipramine [Tr]). The x-axis represents the log base 2 semi-Bayes shrunk adjusted rate ratio for antidepressant + precipitant vs. antidepressant. The y-axis represents the log (1 / p-value) for the semi-Bayes shrunk adjusted rate ratio. Data points in the upper right quadrant represent statistically significant elevated semi-Bayes shrunk adjusted rate ratios for the association between antidepressant + precipitant (vs. antidepressant) and unintentional traumatic injury (i.e., putative drug interaction signals). For ease of reading, we limited labeling to upper right quadrant data points with log base 2 semi-Bayes shrunk adjusted rate ratio ≥1 or log (1 / p-value) for the semi-Bayes shrunk adjusted rate ratio ≥10. MVI = multivitamin with iron, SMX = sulfamethoxazole, TMP = trimethoprim.