Table 2:

Multilevel mixed-effects linear regression of white matter hyperintensity volume^* versus cardiac variables, accounting for family structure (N=782)

Cardiac variable	β (Model 1)	95% CI	β (Model 2)	95% CI
Total coronary plaque volume*	0.07	0.02–0.11	0.07	0.01–0.12
Total calcified coronary plaque volume*	0.06	0.01–0.09	0.06	0.01–0.08
Total non-calcified coronary plaque volume*	0.08	0.01–0.14	0.08	0.04–0.12
Low attenuated coronary plaque volume*	0.06	0.01–0.10	0.06	0.03–0.10
Agatston score* (per 1% higher volume)	0.07	0.01–0.10	0.07	0.03–0.09
Any coronary plaque (versus no plaque)	0.41	0.10–0.70	0.42	0.24–0.59
Agatston score >300 (versus score ≤300)	0.67	0.04–1.04	0.56	0.26–0.89

^*Log transformed, units are per 1 natural log unit unless otherwise noted (original units: white matter hyperintensity 1mm³, plaque volume 0.01mm³)

Abbreviations: β=Beta coefficient, CI=Confidence Interval; Model 1: Age, sex, race, total intracranial volume (TIV); Model 2: Model 1 +total cholesterol (mg/dL), type 2 diabetes (history of type 2 diabetes, fasting glucose level ≥126 mg/dL, and/or use of hypoglycemic medications), smoker (current vs. non), body mass index (kg/m²), systolic blood pressure (mmHg).