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Histone deacetylase classification and cellular localization.
| Class | Informs | Cellular Localization |
|---|---|---|
| I | HDAC1,2,3,8 | nucleus |
| IIa | HDAC4,5,7,9 | cytoplasm and nucleus |
| IIb | HDAC6,10 | |
| III | SIRT1-7 | nucleus (SIRT1,3,6,7) cytoplasm (SIRT2) mitochondria (SIRT3-5) |
| IV | HDAC11 | nucleus |
