Table IV.
Multivariate analysis of factors for progression-free and overall survival after second HCT.
| Variables | Progression Free Survival | Overall Survival | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| History of cGVHD after first HCT | 3.4 | 1.8–6.4 | <0.001 | 2.9 | 1.5–5.7 | 0.001 |
| HCT-CI≥2 | 2.1 | 1.2–3.7 | 0.01 | 2.6 | 1.4–4.9 | 0.003 |
| ≤6 months remission after first HCT | 1.2 | 0.7–2.2 | 0.4 | 2.6* | 1.1–5.8 | 0.02 |
| Second HCT before 2011 | 1.2 | 0.7–1.9 | 0.5 | 2.4* | 1.1–5.1 | 0.02 |
Abbreviations: HCT=hematopoietic cell transplantation; HR=hazards ratio; CI=confidence interval; cGVHD=chronic graft-versus-host disease; HCT-CI=hematopoietic cell transplantation comorbidity index; NS=not significant.
*
Hazard ratios reflect adjustment for a significant interaction effect between transplant decade and duration of remission of first transplant.