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. 2021 Jul 27;12:4541. doi: 10.1038/s41467-021-24731-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Overall structure of WLS-Wnt3a complex. Structure is shown in cartoon with WLS colored in cyan and Wnt3a colored in violet. The sugar moiety on Wnt3a is shown as red sticks, and PAM modified on Wnt3a is shown as green sticks. Key structural elements of Wnt3a at interfaces are indicated. b Fit of WLS-Wnt3a complex model with the 2.2 Å cryo-EM map. Wnt3a is colored in violet and WLS is colored in cyan. The map is generated from the 2.2 Å map in Chimera⁶⁵ at contour level of 0.2 with dust hidden. c Complex structure is shown in surface. Model is colored in same pattern as in Fig. 1b. The contour of hand shape of WLS is shown in orange dash lines. All structural figures are generated with PyMOL⁶⁶.