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. 2021 Jul 27;5:73. doi: 10.1038/s41698-021-00212-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — In the right eye, tumor fraction (Tfx) steadily decreased over the course of 3 IVM injections (A, B, and C) and the TFx percentage calculated by ichorCNA is shown in the top of each genomic profile. The decreases in TFx are accompanied by decreased amplitude of SCNAs, as expected, and decreased tumor burden shown in the matched fundus photos. Of note, the 13q deletion is a germline chromosomal alteration and its amplitude is not affected by decreased TFx.