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. Author manuscript; available in PMC: 2021 Dec 21.
Published in final edited form as: Nat Metab. 2021 Jun 21;3(7):969–982. doi: 10.1038/s42255-021-00406-7

Extended Figure 5. Intracellular iron deficiency blunts nucleotide metabolism.

Extended Figure 5.

(A) Representative patient-derived CRC tumor enteroids were treated with vehicle or DFO (10 μM) (N=3 biologically independent replicates). (B) Quantification of enteroid growth following 4-days of either vehicle or DFO (10 μM) treatment (N=3 biologically independent replicates). (C) Pathway analysis was conducted on metabolomics data in enteroids after DFO treatment before any decrease in growth was seen. Significance was determined by 2-tailed, unpaired t test.