Fig. 1. Single-cell transcriptomes of BAL fluid cells from SARS-CoV-2-infected ferrets.

a Summary of experimental conditions with viral titers in the negative control, at 2 days post-infection (dpi) and 5 dpi. b Histopathologic scoring of the lung tissues of negative control ferrets, and SARS-CoV-2-infected ferrets on 2 and 5 dpi. The scale bar indicates 20 μm. c Fourteen different clusters and their specific marker gene expression levels, where brightness indicates log-normalized average expression, and circle size indicates percent expressed. d UMAP of 59,138 cells from the bronchoalveolar lavage (BAL) fluid of 10 ferrets, colored to show annotated cell types. e The proportion of each cell type at uninfected control (n = 3), 2 dpi (n = 3), and 5 dpi (n = 4). NK natural killer, RBC red blood cell, TCID₅₀ median tissue culture infectious dose. The height of bars indicates mean and error bars indicate standard deviation. Source data are provided as a Source Data file.