Table 1.
Estimated risk of early-onset CRC, CRC at any age, and any age left- and right-sided1 CRC among different relative types of n=1,510 early-onset CRC cases in the UPDB
| . | |||||
|---|---|---|---|---|---|
| Relative | Phenotype in relative | N | Observed | Expected | RR (95% CI) |
| First degree | CRC <50 yr |
11,912 | 64 |
10.7 |
6.00 (4.62, 7.66) |
| Any age CRC | 293 | 111.1 | 2.64 (2.34, 2.96) | ||
| Any age left-sided CRC | 197 | 72.7 | 2.71 (2.34, 3.12) | ||
| Any age right-sided CRC | 121 | 45.2 | 2.67 (2.22, 3.20) | ||
| Second degree | CRC <50 yr |
37,023 | 61 |
19.7 |
3.09 (2.37, 3.97) |
| Any age CRC | 554 | 282.3 | 1.96 (1.80, 2.13) | ||
| Any age left-sided CRC | 383 | 187.2 | 2.05 (1.85, 2.26) | ||
| Any age right-sided CRC | 218 | 116.7 | 1.87 (1.63, 2.13) | ||
| Third degree | CRC <50 yr |
98,192 | 78 |
50.0 |
1.56 (1.23, 1.95) |
| Any age CRC | 898 | 692.4 | 1.30 (1.21, 1.38) | ||
| Any age left-sided CRC | 584 | 457.7 | 1.28 (1.17, 1.38) | ||
| Any age right-sided CRC | 383 | 288.2 | 1.33 (1.20, 1.47) | ||
1
Left-sided CRC includes splenic flexure, descending colon, sigmoid colon, rectosigmoid junction and rectum; right-sided CRC includes cecum, ascending colon, hepatic flexure and transverse colon.