Figure 4:

This figure shows the Ca²⁺ signaling intensity increase over baseline among the responding population of osteocytes for each strain value. Osteocyte Ca²⁺ signaling intensity was elevated in bones loaded to 3000 με. However, there were not significant differences among control, 2d and 28d OVX groups for any strain level examined, indicating that loss of estrogen does not impact the magnitude of Ca²⁺ signaling in osteocytes (@, p<0.05 for 3000 με vs other strain groups.