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. 2021 Jul 27;12(8):744. doi: 10.1038/s41419-021-04016-9

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Increased m6A modification in GCs of aged ovary (OA) compared to the normal ovarian reserve group (NOR), n = 6. B RT-PCR shows the mean expression levels of m6A-associated genes in the GCs in OA and NOR; for FTO, n = 15; and for other genes, n = 10. C Immunohistochemistry (from www.proteinatlas.com) showed the specific expression of FTO in granulosa cells of ovarian tissue. D, E Western blot and immunofluorescence analyses showing the downregulation of FTO in aged granulosa cells compared to young granulosa cells. F Immunofluorescence of γH2A. X and G β-galactosidase staining in FTO-silenced KGN and COV434 cells more readily enter senescence induced by hydrogen peroxide. All experiments were performed three times. The error bars indicate SD; *p < 0.05, **p < 0.01, ***p < 0.001.