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. 2021 Jul 27;12(8):744. doi: 10.1038/s41419-021-04016-9

Fig. 7. Working model. The role of FTO as an m6A demethylase in ovarian aging.

Fig. 7

Aging-related factors (ROS) downregulate the demethylase FTO in ovarian granulosa cells, which can enhance FOS-mRNA stability by increasing m6A in the FOS-mRNA-3′UTR to upregulate FOS expression, thus leading to ovarian aging.