Table 1.

Description of characteristics of included studies.

Study	Country	Type of bleed	Design	Method of diagnosis	Groups	Men (n)	Women (n)	Duration offollow-up	Duration of treatment	Treatment protocol	Clinical score
Chandra 1978	Indonesia	SAH	RCT	Lumbar puncture + angiography	TXA and control	21	18	21 days	3 weeks	IV or Per Mouth1g/4 h	Own
Fodstad 1978	Sweden	SAH	RCT	Lumbar puncture + angiography	TXA and control	23	23	> 3 months	6 weeks	IV 1 g/4 h 1w then 1 g/6 h 4w then 1 g/8 h 1w	Botterell
Fodstad 1981	Sweden	SAH	RCT	Lumbar puncture + angiography	TXA and control	22	19	90 days	5 weeks	IV 1 g/4 h 1w then 1 g/6 h 4w	Botterell
Gelmers 1980	Netherlands	SAH	Non-RCT	Lumbar puncture	TXA and control	26	31	90 days	3 months	IV 1 g/6 h	Botterell
Gibbs 1971	UK	SAH	RCT	Angiography	TXA and control	17	30	2 months	3 weeks	Per Mouth 3 g/day	?
Hillman 1997	Sweden	SAH	RCT	CT-scan	TXA and control	330	175	> 3 months	3 days	IV 1 g bolus then 1 g 2 h after bolus then 1 g/6 h	Hunt and Hess
Kaste 1979	Finland	SAH	RCT	Lumbar puncture	TXA and control	30	34	21 days	21 days	IV 1 g/4 h	Botterell
Maurice-Williams 1978	UK	SAH	RCT	Angiography	TXA and control	?	?	42 days	42 days	IV 1 g/4 h 1w then 1.5 g/6 h per mouth	Botterell
Meretoja 2020	Australia	ICH	RCT	CT-scan	TXA and control	52	48	90 days	?	IV 1 g bolus then 1 g/8 h	Glasgow/NIHSS
Post 2021	Netherlands	SAH	RCT	CT-scan	TXA and control	312	644	30 days	1 day	IV 1 g bolus then 1 g/8 h	WFNS
Sprigg 2014	UK	ICH	RCT	CT-scan	TXA and control	14	10	90 days	?	IV 1 g bolus then 1 g/8 h	Glasgow/NIHSS
Sprigg 2018	UK	ICH	RCT	CT-scan	TXA and control	1301	1024	90 days	?	IV 1 g bolus then 1 g/8 h	Glasgow/NIHSS
Tsementzis 1990	UK	SAH	RCT	Angiography	TXA and control	46	54	28 days	4 weeks	IV 1.5 g/4 h	Botterell
Van Rossum 1977	Netherlands	SAH	RCT	Lumbar puncture	TXA and control	?	?	90 days	10 days	IV 1 g/6 h	?
Vermeulen 1984	Netherlands	SAH	RCT	Angiography	TXA and control	189	290	90 days	4 weeks	IV 1 g/4 h 1w then 1 g/6 h 3w	Hunt and Hess