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. 2021 Jul 27;12:4548. doi: 10.1038/s41467-021-24799-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Images of kidneys (top panel) and axial MRI images (bottom panel) from Pkd1^RC/RC mice treated with or without GW4869. Scale bars, 5 mm. b Histological examination of kidneys from Pkd1^RC/RC mice treated with or without GW4869. Scale bars, 1 mm. c MRI images from Pkd1^RC/RC mice treated with or without GW4869. Scale bars, 1 mm. d Treatment with GW4869 deceased cystic index in kidneys from Pkd1^RC/RC mice (n = 5) compared to that in kidneys from control mice treated with DMSO (n = 5). Treatment with GW4869 decreased KW/BW ratios (e) and BUN levels (f) in Pkd1^RC/RC mice compared to those in kidneys from control mice treated with DMSO. g Total kidney volume (TKV) was calculated by MRI scan in each group. h Histological examination of kidneys from wild-type mice treated with GW4869 (n = 5). Scale bars, 1 mm. Treatment with GW4869 did not affect KW/BW ratios (i) and BUN levels (j) in GW4869-treated wild-type mice compared to the controls. All statistical data are represented as mean ± SEM, and p values are calculated by unpaired Student’s t-test.