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Wnk1 knockout is lethal in immortalized macrophages with fully functional NLRP3 inflammasome activity.
| #Clones tested | #WT clones | #Het clones | #KO clones | |
|---|---|---|---|---|
| Wild type | 31 | 27 | 4 | 0 |
| Rip1 KO | 36 | 31 | 5 | 0 |
| NLRP3 KO | 18 | 10 | 5 | 3 |
| Caspase 1 KO | 18 | 14 | 1 | 3 |
| ASC KO | 36 | 20 | 8 | 8 |
