Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 27;12:4543. doi: 10.1038/s41467-021-24482-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Overview of COVID-19 patient enrollment criteria and study design, including multi-omics profiling of blood samples from COVID-19 patients spanning four disease severities (asymptomatic (asym), mild, severe, and critical). Venn diagram showing overlapping samples profiled using WGS, RNA-seq, and LC-MS. b Bar plot showing the numbers of significantly differentially expressed mRNAs, proteins, metabolites, and lipids in six groups of comparison. The mRNA analysis included asymptomatic (n = 64), mild (n = 64), severe (n = 34), and critical (n = 16) COVID-19 patients. P values for mRNAs were calculated using Wald test (two-sided). The proteins, metabolites, and lipids analysis included asymptomatic (n = 53), mild (n = 54), severe (n = 33), and critical (n = 21) COVID-19 patients. P values for proteins, lipids and metabolites were calculated using Mann–Whitney U test (two-sided). Multiple comparisons adjustment was performed using Benjamini-Hochberg (BH) method. Exact P value and source data were included in the Source Data file.