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. 2021 Jul 27;12:4549. doi: 10.1038/s41467-021-24800-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Weight in grams of Dnmt3a^+/+ control mice (red, n = 90) and Dnmt3a^R878H/+ mice (blue, n = 120) from weaning (day 21) to 575 days of age. Linear regression analysis was used to determine differences between genotypes (p ≤ 0.0001). b Representative image of age and gender-matched littermate Dnmt3a^+/+ (30.9 g) vs. Dnmt3a^R878H/+ (59.45 g) mice highlighting a typical size difference at 1 year of age. c Representative CT images of femurs from whole mouse imaging. Measurements of femur length (mm) in Dnmt3a^+/+ and Dnmt3a^R878H/+ age-matched controls are shown (n = 4 each genotype). d Quantification of femur lengths (mm) measured as shown in b (n = 4 biologically independent samples/genotype, P = 0.0049 by two-tailed t test). e Quantification of humerus lengths (mm) in the same mice, measured by CT scan (n = 4 biologically independent samples/genotype, p-value by two-tailed t test). f Reconstructions of cranium and mandible from CT scans of Dnmt3a^+/+ and Dnmt3a^R878H/+ mice showing landmarks of differences in size and angles. g The MRI quantification of body fat composition of age-matched Dnmt3a^+/+ (red, n = 4) and Dnmt3a^R878H/+ (blue, n = 7) pairs separated by age (less or greater than 6 months), to highlight age-dependent increases in body fat (P-values by two-way ANOVA with Tukey’s multiple comparisons test are indicated). h The MRI quantification of lean body mass composition of age-matched Dnmt3a^+/+ (red, n = 4) and Dnmt3a^R878H/+ (blue, n = 7) pairs separated by age (less or greater than 6 months). i Quantification of chow consumed (calculated as grams of chow per mouse per day) for age-matched Dnmt3a^+/+ (red, n = 8) and Dnmt3a^R878H/+ (blue, n = 8) mice (P = 0.0013 by two-tailed t test). j Weight tracking in grams of Dnmt3a^+/+ control mice (red, n = 4) and Dnmt3a^R878H/+ mice (blue, n = 6) fed a high-fat diet from 100 to 300 days of age. Linear regression analysis was used to determine differences between genotypes (p ≤ 0.0001). For d, e, g-i error bars show mean ± SEM. g grams, mm millimeter.