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. 2021 Jul 27;12:4549. doi: 10.1038/s41467-021-24800-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Total ambulations during 1-hour open-field testing, split into 10-minute intervals (p = 0.0013 effect by genotype, F_(1,32) = 12.5, n = 17,17; two-way repeated-measures ANOVA with Šídák’s multiple comparison test). b The number of rearing events during 1-hour open-field testing, split into 10-minute intervals (p = 0.0183 effect by genotype, F_(1,32) = 6.183, n = 17,17; two-way repeated-measures ANOVA with Šídák’s multiple comparison test). Dnmt3a^R878H/+ mice take significantly longer to c climb down a pole (p ≤ 0.0001, n = 17,17; unpaired t test), reach the top of a d 60° inclined screen (p = 0.0041, n = 17,17; unpaired t test) and e 90° inclined screen (p = 0.0118, n = 17,17; unpaired t test). Panels f–h The percentage of time freezing in f conditioned fear training (cue: p ≤ 0.0001 genotype effect, F_(1,31) = 28.02, n = 16,17; two-way repeated-measures ANOVA with Šídák’s multiple comparison test), g contextual fear trials (p = 0.0002 genotype effect, F_(1,31) = 18.53, n = 16,17; two-way repeated-measures ANOVA with Šídák’s multiple comparison test) and h cued fear trials (baseline: p = 0.0009 genotype effect, F_(1,31) = 31.02; cue: p = 0.0026 genotype effect F_(1,31) = 10.76, n = 16,17; two-way repeated-measures ANOVA with Šídák’s multiple comparison test). i Minimum shock needed to exhibit a behavioral response in mice during conditioned fear test (escape: p = 0.0064 genotype effect F_(1,31) = 5.094, n = 16,17; two-way repeated-measures ANOVA with Šídák’s multiple comparison test). The box extends from 25th to 75th percentile, the line indicates median and whiskers show 10th to 90th percentile. j Marbles buried in 30 min (5 min bins, p = 0.0181, genotype effect F_(1,28) = 6.307, n = 15,15; two-way repeated-measures ANOVA with Šídák’s multiple comparison test). *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. The line and bar graphs indicate the mean and SEM for each value tested. min minutes, s seconds, mA milliamps.