Table 2.
Epidemiological and genomic evidence for nosocomial acquisition of SARS-CoV-2 based on classification of 803 PCR-positive hospital in-patients.
| Definite nosocomial | Probable nosocomial | Indeterminate | Community-onset | |||||
|---|---|---|---|---|---|---|---|---|
| Epidemiological evidence | ||||||||
| Standard epidemiological classification* | 51 | 58 | 79 | 615 | ||||
| Enhanced epidemiological classification provides support for nosocomial acquisition (n,%)⁎⁎ | Yes | No | Yes | No | Yes | No | Yes | No |
| 51 (100%) | 0 | 56 (97%) | 2 (3%) | 53 (67%) | 26 (33%) | 89 (14%) | 526 (86%) | |
| Donor/recipient closest epidemiological link identifiedWard contactHospital contact | 465 | 00 | 533 | 20 | 512 | 242 | 6920 | 00 |
| Combined epidemiological and genomic evidence | ||||||||
| Recipient and one or more epidemiological donor(s) sequenced (n,%)^Ward contactHospital contact | 25/46 (54%)1/5 (20%) | 00 | 37/53 (70%)2/3 (67%) | 1/2 (50%)0 | 29/51 (57%)1/2 (50%) | 15/24 (63%)1/2 (50%) | 37/69 (54%)5/20 (25%) | 00 |
| Genomic linkage confirmed (n,%)^^Ward contactHospital contact | 17/25 (68%)1/1 (100%) | 00 | 32/37 (86%)1/2 (50%) | 1/1 (100%)0 | 22/29 (76%)1/1 (100%) | 6/15 (40%)0/1 (0%) | 17/37 (46%)0/5 (0%) | 00 |
Nosocomial classification according to national Public Health England definition.
Enhanced epidemiological classification for nosocomial acquisition, using prior negative PCR in the same admission, or previous hospital admission during the incubation period to provide additional support for nosocomial acquisition. Figures demonstrate number and% of nosocomial category.
^Figures presented as number sequenced over total number of recipients with one or more ward or hospital contacts identified
^^Figures presented as number genomically linked over total number of recipients sequenced, for ward contacts or hospital contacts.