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. 2021 Jul 14;12:722175. doi: 10.3389/fphar.2021.722175

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Copyright © 2021 Lai, Mo, Wang, Zhong, Lu, Wang, Cui, Liu and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of tanshinol on bone metabolism in GIO rats. (A) Toluidine blue staining of cancellous bone of the proximal tibia metaphysis. (B) Histomorphometric results of Oc.s/BS, OC.N, and Ob.s/BS of cancellous bone of proximal tibial metaphysis. (C) Static parameters of proximal tibial metaphysis in cancellous bone. (D) Serum markers of bone formation (PINP) and bone resorption (β-CTX) measured by using ELISA assay. The data are presented as the mean ± SD (n = 9). Note: ^∗ p < 0.05, ^∗∗ p < 0.01, ^∗∗∗ p < 0.001versus Con; ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 versus GC.