Fig. 3.

Hypothetical injection interval when combining two or more long-acting injectable antipsychotics (LAIA) once-monthly. Solid line means LAI A existing injection and two dashed lines indicate LAI B newly injected. New LAI B can be administered simultaneously (tight dashed line, Sim) every 4 weeks along with an existing LAI A or injected alternatively (wide dashed line, Alt) every 2 weeks with existing LAI A depending on clinical situation and patients’ preference. Simultaneous injection can be useful for those want less frequent shots and are relatively in stable clinical status, while alternating injection can be beneficial for patients who need more close observation, are more compliant and are sensitive to injection pain. In case of switching from existing LAI A/B to LAI A/C, a new LAI C can be administered in place of the next injection of existing LAI B (not shown in figure). AP, antipsychotic polypharmacy.