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Design and characterization of tetravalent nAbs. (A) Schematic of the bivalent IgG format, and the tetravalent Fab-IgG and IgG-Fab formats. Paratopes are shown in red, linkers are shown in black, and disulfide bonds are shown as yellow spheres. (B) Analytical gel filtration SEC of nAbs. (C) SDS-PAGE analysis of nAbs under non-reducing (top) or reducing conditions (bottom). (D) BLI sensor traces for nAbs (6.7 nM) binding to immobilized S-protein trimer.
