TABLE 3.

Genes associated with aripiprazole pharmacokinetics or pharmacodynamics.

Aripiprazole
Pharmacokinetics
Gene	Variant	Association	Associated	Not associated
CYP2D6	PM	↑Cmax, ↑T1/2	(Kinghorn and McEvoy, 2005; Belmonte et al., 2018)
CYP3A4	*6	No effect		Sanchez Spitman et al. (2017)
	*20	No effect		Sanchez Spitman et al. (2017)
	*26	No effect		Sanchez Spitman et al. (2017)
CYP3A5	*3/*3	↑[Aripiprazole]plasma	Suzuki et al. (2014)	Belmonte et al. (2018)
ABCB1	rs1045642	↓[Aripiprazole]plasma	Rafaniello et al. (2018)	(Suzuki et al., 2014; Belmonte et al., 2018; Koller et al., 2018)
	rs2032582	↓[Aripiprazole]plasma	(Belmonte et al., 2018; Rafaniello et al., 2018)	(Suzuki et al., 2014; Belmonte et al., 2018; Koller et al., 2018)
		↓Cl
	rs1128503	↓Cl	Belmonte et al. (2018)
Pharmacodynamics
5-HTR2A	rs6311	↓Response for negative symptoms	Chen et al. (2009)
DRD2	rs1800497	↑Response for negative symptoms	(Kwon et al., 2008; Ramsay et al., 2015)
		↓Cognitive performance
	rs6277	↓Response to aripiprazole, ↓Cognitive performance	(Shen et al., 2009; Ramsay et al., 2015)