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. 2021 Jul 14;15:706786. doi: 10.3389/fnins.2021.706786

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Copyright © 2021 Zhou, Cai, Wang, Wu, Yin, Wang, Hu, Wang, Tan and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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rTMS ameliorated CPZ-induced cognitive impairment and demyelination in mice. (A) Schematic diagram displaying the time course of rTMS treatment in a CPZ-induced mouse model of demyelination. C57BL/6 mice were administered CPZ for 6 weeks to induce demyelination, and rTMS was administered for 1 week after the conclusion of CPZ administration. (B–D) In the Y-maze test, CPZ-treated mice showed impaired spatial working memory and spatial cognitive ability, which was restored by rTMS. (E,F) In the 3-chamber test, mice in the CPZ group showed reduced social interactions and weaker social memory. Mice in the CPZ + rTMS group performed better than those treated with CPZ alone. (G–I) Representative immunoblots and densitometry analysis of MBP in the hippocampus, PFC, and striatum in the sham, CPZ, and CPZ + rTMS groups. E, empty wire-cup; S1, subject 1; S2, subject 2.