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. 2021 Jul 14;15:706786. doi: 10.3389/fnins.2021.706786

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Copyright © 2021 Zhou, Cai, Wang, Wu, Yin, Wang, Hu, Wang, Tan and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alteration of lipidomic profiles and the characterization of lipids in the hippocampus of mice in each group. Six main lipid classes were analyzed: (A) glycerophospholipids, (B) fatty acyls, (C) sphingolipids, (D) glycerolipids, (E) saccharolipids, and pernol lipids. Lipids showing low levels results have been enlarged in insets. (F,G) Forest plots of individual lipids in the hippocampus of mice in the CPZ group expressed as a percent difference compared to shams, CPZ + rTMS group expressed as a percent difference compared to the CPZ group. Molecules indicated in green represent significant differences in individual lipids (P < 0.05). Lipids highlighted in yellow indicate lipids that were modulated in a contrary direction compared to that in the CPZ group. PC, phosphatidylcholine; PE, phosphatidylethanolamine; PG, phosphatidylglycerol; PI, phosphatidylinositol; PS, phosphatidylserine; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; LPG, lysophosphatidylglycerol; LPI, lysophosphatidylinositol; LPS, lysophosphatidylserine; PA, phosphatidic acid; AcCa, acylcarnitine; FA, fatty acid; WE, wax esters; Cer, ceramides; CerG, glucosylceramides; SM, sphingomyelin; phSM, sphingomyelin (phytosphingosine); ST, sulfatides; So, sphingosine; CerP, ceramide phosphates; DG, diglyceride; TG, triglyceride; MG, monoglyceride; MGDG, monogalactosyldiacylglycerol; SQDG, sulfoquinovosyldiacylglycerol; Co, coenzyme. *P < 0.05 vs. sham; **P < 0.01 vs. sham; ^#P < 0.05 vs. CPZ; ^##P < 0.01 vs. CPZ.