. 2021 May 4;22(8):1225–1239. doi: 10.3348/kjr.2020.1210

Table 3. Summary of Studies Using AI-CAD for DBT Interpretation.

References	No. of Readers	No. of DBT Exams	Software Used	Reading Time	AUC		Sensitivity (%)		Specificity (%)		Recall Rates (%)
References	No. of Readers	No. of DBT Exams	Software Used	Reading Time	Without CAD	With CAD	Without CAD	With CAD	Without CAD	With CAD	Without CAD	With CAD
Balleyguier et al. 2017 [39]	6	80 (23 cancers)	PowerLook Tomo Detection, iCAD	↓ 48.2 sec^†	0.854	0.850	86.5	86.5	57.6	56.2	42.7	45.2
Balleyguier et al. 2017 [39]	6	80 (23 cancers)	PowerLook Tomo Detection, iCAD	↓ 23.5%	0.854	0.850	86.5	86.5	57.6	56.2	42.7	45.2
Benedikt et al. 2018 [40]	20	240 (60 cancers)	PowerLook Tomo Detection, iCAD^*	↓ 19.6 sec^†	0.841	0.850	84.7	87.1	52.7	50.9	47.4	49.2
Benedikt et al. 2018 [40]	20	240 (60 cancers)	PowerLook Tomo Detection, iCAD^*	↓ 29%	0.841	0.850	84.7	87.1	52.7	50.9	47.4	49.2
Chae et al. 2019 [41]	4	100 (70 cancers)	In-house DBT CAD system	↓ 10.04 sec^†	0.778	0.776	77.5	78.6	66.7	66.7	-	-
Chae et al. 2019 [41]	4	100 (70 cancers)	In-house DBT CAD system	↓ 14%	0.778	0.776	77.5	78.6	66.7	66.7	-	-
Conant et al. 2019 [35]	24	260 (65 cancers)	PowerLook Tomo Detection, iCAD	↓ 34.7 sec^†	0.795	0.852	77.0	85.0†	62.7	69.6†	38.0	30.9^†
Conant et al. 2019 [35]	24	260 (65 cancers)	PowerLook Tomo Detection, iCAD	↓ 52.7%	0.795	0.852	77.0	85.0†	62.7	69.6†	38.0	30.9^†

^*CAD system focuses on detecting soft tissue lesions and does not detect calcifications, ^†With statistical significance. AI = artificial intelligence, AUC = area under the receiving operator characteristics curve, CAD = computer-aided detection/diagnosis, DBT = digital breast tomosynthesis