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. 2021 Jul 28;11(7):210080. doi: 10.1098/rsob.210080

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© 2021 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 5. — The GOAT acyl-donor binding site selects for an eight-carbon acyl chain. (a) The acyl-donor binding site is exposed on the cytoplasmic face of GOAT; (b) Cutaway view of the acyl chain of octanoyl-CoA binding into a hydrophobic pocket within the enzyme internal channel. (c) Alanine mutagenesis of residues contacting octanoyl-CoA leads to either reduction (purple) or complete loss (red) of enzyme acylation activity. Figure reproduced from reference [115] under the terms of the Creative Commons CC-BY licence.