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. 2021 Jul 28;11(7):210080. doi: 10.1098/rsob.210080

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© 2021 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 8. — Proposed reaction cycle for transmembrane ghrelin octanoylation by GOAT. The two substrates for GOAT, ghrelin (GSSFL-ghrelin) and octanoyl-CoA, enter the enzyme internal channel from the ER lumen and cytoplasm, respectively. Acyl transfer of the octanoyl chain to the ghrelin serine hydroxyl is catalysed by interaction with His-338, followed by octanoylated ghrelin dissociation to the ER lumen and coenzyme A release back to the cytoplasm. Figure created with BioRender.com.