Table 2.

DNA methyltransferase inhibitors in clinical trial for brain cancer treatment

Compound	Class	Target	Conditions	Phase of clinical trial	Study title
5-Azacytidine	DNMTi	Pan-DNMT	Brain tumor recurrent	Early Phase 1	Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle in Children With Recurrent Posterior Fossa Ependymoma
Azacitidine	DNMTi	Pan-DNMT	GBM multiformeOther	Phase 1	Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies
5-Azacytidine	DNMTi	Pan-DNMT	Recurrent childhood CNS tumor	Phase 1	Treatment of Children With Recurrent Refractory Brain/Solid Tumors and Recurrent Ependymoma
			Ependymoma, recurrent childhood
			Childhood solid tumor

DNMT: DNA methyltransferase; DNMTi: DNMT inhibitors; CNS: Central nervous system; GBM: Glioblastoma.