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. 2021 Jul 14;8:681526. doi: 10.3389/fmolb.2021.681526

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Copyright © 2021 Zhang, Dai, Zhao, Zhou, An, Tang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PCA plots and differential analysis of GSE17590, GSE80060, and GSE112057. (A) PCA plots of the three datasets. Each point in the scatter plots represents a GSM sample. (B) Heat maps of the top 100 DEGs between HC and sJIA patients. (C) Volcano plots of the DEGs between HC and sJIA patients. The blue dots represent significantly downregulated genes the red dots significantly upregulated genes in sJIA patients; hub genes are marked. (D) Venn diagram showing overlapping DEGs of the three datasets. PCA, principal component analysis; DEGs, differentially expressed genes; HC, healthy control; sJIA, systemic juvenile idiopathic arthritis.