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. 2021 Jul 14;8:681526. doi: 10.3389/fmolb.2021.681526

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Copyright © 2021 Zhang, Dai, Zhao, Zhou, An, Tang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment analysis. (A) Significantly enriched Gene Ontology terms of co-DEGs. (B) Significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways of co-DEGs. (C) Network of representative enriched terms of co-DEGs. Each node represents an enriched term and is colored by cluster identity. (D) The same enrichment network with its nodes colored by p values. (E) Top 20 pathways related to co-DEGs based on comprehensive enrichment analysis using the GO, KEGG, and Reactome databases. (F-H) Significantly enriched gene set enrichment analysis pathways between HCs and sJIA patients in the GSE17590, GSE80060, and GSE112057 datasets. Co-DEGs, common differentially expressed genes.