FIGURE 4.

Hub gene identification, functional annotation and diagnosis prediction analysis. (A) PPI network of co-DEGs; nodes in pink denote the highly interconnected region identified by “MCODE”. (B) Networks of the six hub genes identified by “cytoHubba”. The yellow to red color scale denotes the p value calculated by the MCC method. (C) Functional heat map of the six hub genes based on literature mining. Green indicates that a gene term has been reported to have a positive association, and black indicates that the gene term has not been reported to have an association. In the left-most lane, green indicates the proportion of genes associated with the term. (D) Diagnostic utility of the six hub genes in the three datasets. PPI, protein-protein interaction; co-DEGs, common differentially expressed genes; ROC, receiver operating characteristic; AUC, area under the ROC curve.