Table 1.
List of the six overlapping ORFs detected in SARS-CoV-2.
| ORF name | Type of experimental evidence for expression or function | Type of computational method for detection |
|---|---|---|
| ORF2b | Ribosome profiling (Finkel et al., 2021), immunopeptidomics (Weingarten-Gabbay et al., 2020) | – |
| ORF3b | Interferon antagonist, when expressed from a plasmid in Sendai-virus infected cells (Konno et al., 2020) | – |
| ORF3c | Ribosome profiling (Finkel et al., 2021) | Synplot2 (Firth, 2014, 2020), PhyloCSF (Lin et al., 2011; Jungreis et al., 2021b) |
| ORF3d | Ribosome profiling (Finkel et al., 2021), antibodies (Hachim et al., 2020) | Codon permutation method (Schlub et al., 2018; Nelson et al., 2020b), sequence-composition method (Pavesi, 2020) |
| ORF9b | Ribosome profiling (Finkel et al., 2021), immunopeptidomics (Weingarten-Gabbay et al., 2020), suppressor of interferon response (Jiang et al., 2020) | GOFIX (Michel et al., 2020), PhyloCSF (Lin et al., 2011; Jungreis et al., 2021b) |
| ORF9c | Suppressor of antiviral response, when expressed from a plasmid in transfected cells (Dominguez Andres et al., 2020) | GOFIX (Michel et al., 2020), sequence-composition method (Pavesi, 2020) |