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. 2021 Jul 27;4(7):e2114501. doi: 10.1001/jamanetworkopen.2021.14501

Figure 1. Model Structure.

Figure 1.

The Markov cohort model used in this study simulated a hypothetical cohort of patients with heart failure with reduced ejection fraction (HFrEF) with clinical characteristics similar to the participants of the Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction trial. The model compared guideline-directed medical therapy (GDMT) in the control arm with dapagliflozin added to GDMT in the intervention arm. In monthly cycles, patients could continue to live with HF, experience an urgent HF visit, experience a HF hospitalization (with or without a readmission in the first 30 days after the index hospitalization), develop incident diabetes, or die from any cause.