Table 2.

Univariate Cox regression analysis of overall survival and cancer-specific survival in cervical squamous cell carcinoma (training cohort).

Variables	Overall survival			Cancer-specific survival
	HR	95%CI	P	HR	95%CI	P
Age
≤38	Reference			Reference
39-47	1.265	1.148-1.394	<0.001*	1.178	1.062-1.306	0.002
48-58	1.796	1.634-1.973	<0.001*	1.561	1.410-1.727	<0.001*
≥59	2.804	2.566-3.064	<0.001*	1.837	1.662-2.030	<0.001*
Race
White	Reference			Reference
Black	1.381	1.274-1.498	<0.001*	1.372	1.251-1.504	<0.001*
Other	0.957	0.864-1.061	0.403	0.943	0.838-1.061	0.327
Year of diagnosis
≤1996	Reference			Reference
1997-2004	0.881	0.803-0.966	0.007	0.853	0.766-0.950	0.004
≥2005	0.895	0.817-0.981	0.017	0.862	0.778-0.955	0.004
Histologic grade
Grade I	Reference			Reference
Grade II	1.580	1.357-1.840	<0.001*	1.853	1.535-2.236	<0.001*
Grade III	2.141	1.842-2.489	<0.001*	2.609	2.167-3.142	<0.001*
Grade IV	2.078	1.607-2.687	<0.001*	2.588	1.924-3.481	<0.001*
Clinical stage
Stage I	Reference			Reference
Stage II	2.688	2.445-2.956	<0.001*	3.188	2.833-3.588	<0.001*
Stage III	3.531	3.255-3.832	<0.001*	4.869	4.404-5.384	<0.001*
Stage IV	10.373	9.474-11.356	<0.001*	15.028	13.503-16.726	<0.001*
Tumor size
≤28	Reference			Reference
29-69	3.347	3.071-3.648	<0.001*	4.724	4.219-5.290	<0.001*
≥70	6.276	5.699-6.912	<0.001*	9.692	8.586-10.942	<0.001*
Metastasis
M0	Reference			Reference
M1	5.252	4.857-5.678	<0.001*	6.193	5.700-6.729	<0.001*
Radiotherapy
No/Unknown	Reference			Reference
Yes	2.675	2.482-2.884	<0.001*	3.037	2.775-3.323	<0.001*
Chemotherapy
No/Unknown	Reference			Reference
Yes	1.842	1.731-1.961	<0.001*	2.161	2.011-2.323	<0.001*
Historic stage
Localized	Reference			Reference
Regional	3.367	3.118-3.636	<0.001*	4.481	4.064-4.941	<0.001*
Distant	10.999	10.001-12.096	<0.001*	16.240	14.513-18.173	<0.001*

HR, hazard Ratio; CI, confidence interval; *P < 0.05 were considered statistically significant.