Table 3.
Multivariate Cox regression analysis of overall survival and cancer-specific survival in cervical squamous cell carcinoma (training cohort).
| Variables | Overall survival | Cancer-specific survival | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | P | HR | 95%CI | P | |
| Age | ||||||
| ≤38 | Reference | Reference | ||||
| 39-47 | 1.073 | 0.974-1.183 | 0.153 | 0.974 | 0.878-1.081 | 0.623 |
| 48-58 | 1.317 | 1.197-1.449 | <0.001* | 1.076 | 0.971-1.193 | 0.161 |
| ≥59 | 2.093 | 1.911-2.293 | <0.001* | 1.296 | 1.170-1.436 | <0.001* |
| Race | ||||||
| White | Reference | Reference | ||||
| Black | 1.319 | 1.216-1.431 | <0.001* | 1.300 | 1.185-1.426 | <0.001* |
| Other | 0.831 | 0.750-0.922 | <0.001* | 0.861 | 0.764-0.969 | 0.013 |
| Year of diagnosis | ||||||
| ≤1996 | Reference | Reference | ||||
| 1997-2004 | 0.993 | 0.902-1.093 | 0.888 | 0.943 | 0.843-1.054 | 0.303 |
| ≥2005 | 0.961 | 0.872-1.060 | 0.429 | 0.913 | 0.817-1.019 | 0.105 |
| Histologic grade | ||||||
| Grade I | Reference | Reference | ||||
| Grade II | 1.137 | 0.975-1.325 | 0.102 | 1.224 | 1.013-1.478 | 0.036 |
| Grade III | 1.275 | 1.095-1.484 | 0.002 | 1.391 | 1.154-1.678 | <0.001* |
| Grade IV | 1.237 | 0.956-1.601 | 0.106 | 1.334 | 0.991-1.797 | 0.058 |
| Clinical stage | ||||||
| Stage I | Reference | Reference | ||||
| Stage II | 1.179 | 0.926-1.500 | 0.182 | 1.171 | 0.871-1.573 | 0.295 |
| Stage III | 1.661 | 1.310-2.105 | <0.001* | 1.832 | 1.372-2.446 | <0.001* |
| Stage IV | 3.056 | 2.291-4.077 | <0.001* | 3.519 | 2.511-4.933 | <0.001* |
| Tumor size | ||||||
| ≤28 | Reference | Reference | ||||
| 29-69 | 2.071 | 1.879-2.282 | <0.001* | 2.681 | 2.366-3.039 | <0.001* |
| ≥70 | 3.051 | 2.726-3.415 | <0.001* | 4.110 | 3.577-4.722 | <0.001* |
| Metastasis | ||||||
| M0 | Reference | Reference | ||||
| M1 | 0.998 | 0.732-1.360 | 0.989 | 1.058 | 0.759-1.476 | 0.739 |
| Radiotherapy | ||||||
| No/Unknown | Reference | Reference | ||||
| Yes | 1.115 | 1.014-1.226 | 0.024 | 1.034 | 0.925-1.156 | 0.559 |
| Chemotherapy | ||||||
| No/Unknown | Reference | Reference | ||||
| Yes | 0.745 | 0.688-0.807 | <0.001* | 0.772 | 0.704-0.845 | <0.001* |
| Historic stage | ||||||
| Localized | Reference | Reference | ||||
| Regional | 1.539 | 1.212-1.954 | <0.001* | 1.842 | 1.371-2.474 | <0.001* |
| Distant | 2.265 | 1.522-3.371 | <0.001* | 2.652 | 1.688-4.166 | <0.001* |
HR, hazard Ratio; CI, confidence interval; *P < 0.05 were considered statistically significant.