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. 2021 Jul 14;12:693579. doi: 10.3389/fimmu.2021.693579

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Copyright © 2021 Wang, Zhou, Fu and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall topology of the SARS-CoV-2 spike monomer. The secondary structure of the spike monomer contains two parts, S1 and S2. S1 is composed of an NTD (shown in black) and CTD (shown in blue) containing the receptor binding domain (RBD) necessary for hACE2 binding. (Expasy Reference Sequence: P0DTC2).