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. 2021 Jul 14;12:693579. doi: 10.3389/fimmu.2021.693579

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Copyright © 2021 Wang, Zhou, Fu and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SARS-like CoVs including SARS-CoV, MERS-CoV and SARS-CoV-2 inhibit host IFN signalling pathway. Proteins of SARS-CoV are in green, proteins of MERS-CoV in violet and proteins of SARS-CoV-2 in blue. The IFN upstream pathways are in the left side of the figure and the IFN downstream pathways are in the right side. The pattern diagram of SARS-CoV-2 is credited by Maria Voigt/RCSB PDB.