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. 2021 Jul 14;12:699712. doi: 10.3389/fphys.2021.699712

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Copyright © 2021 Wiley, Perez, Argueta, Avalos, Wood and DiPatrizio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activity of the MAG biosynthetic enzyme, DGL, in mouse small-intestinal epithelium was dose-dependently inhibited by the DGL inhibitor, THL (A) IC₅₀ = 136.3 nM. Activity of the MAG degradative enzyme, MGL, in small-intestinal epithelium was dose-dependently inhibited by the MGL inhibitor, JZL 184 (B) IC₅₀ = 47.62 nM. Activity of the FAE degradative enzyme, FAAH, in small-intestinal epithelium was inhibited by the FAAH inhibitor, URB597 (C) IC₅₀ = 40.76 nM.