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. Author manuscript; available in PMC: 2021 Nov 9.
Published in final edited form as: ACS Infect Dis. 2021 Mar 25;7(7):1969–1984. doi: 10.1021/acsinfecdis.1c00055

Figure 5.

Figure 5.

Human cell toxicity of carbonic anhydrase inhibitor analogs 20 (blue) and 23 (red) compared to DMSO control (green). (A) Cell viability in human endocervical (End1/E6E7) cells using the MTS; 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay. (B) Cell viability in human colorectal ladenocarcinoma (Caco-2) cells. Results are presented as percent viable cells relative to DMSO (negative control to determine a baseline measure for the cytotoxic impact of each compound). The absorbance values represent an average of three samples analyzed for each compound. Error bars represent standard deviation values. Data were analyzed via a two-way ANOVA with post hoc Dunnett’s test for multiple comparisons.