Table 2.
MICs for Selected Analogs against a panel of N. gonorrhoeae clinical isolates
| MIC (μg/mL) |
||||
|---|---|---|---|---|
| N. gonorrhoeae strains | AZM | 20 | 23 | AZI |
| CDC 165 | 4 | 1 | 4 | 2 |
| CDC 166 | 4 | 1 | 2 | 2 |
| CDC 167 | 2 | 0.5 | 4 | 4 |
| CDC 168 | 4 | 0.5 | 4 | 1 |
| CDC 169 | 4 | 0.25 | 2 | 1 |
| CDC 170 | 1 | 0.125 | 0.5 | 1 |
| CDC 171 | 2 | 0.5 | 2 | 1 |
| CDC 173 | 1 | 0.125 | 0.5 | 0.5 |
| CDC 175 | 2 | 0.25 | 2 | 4 |
| CDC 176 | 1 | 0.25 | 1 | 0.5 |
| CDC 177 | 1 | 0.5 | 2 | 0.5 |
| CDC 178 | 2 | 1 | 0.5 | 2 |
| CDC 179 | 4 | 2 | 4 | 4 |
| CDC 180 | 2 | 0.5 | 2 | 0.5 |
| CDC 181 | 2 | 0.5 | 0.25 | >64 |
| CDC 182 | 4 | 0.5 | 2 | 1 |
| CDC 183 | 2 | 0.25 | 2 | 1 |
| CDC 184 | 2 | 0.25 | 2 | 1 |
| CDC 185 | 4 | 0.5 | 2 | 1 |
| CDC 187 | 2 | 0.25 | 2 | 4 |
| CDC 189 | 2 | 0.06 | 1 | 0.5 |
| CDC 190 | 2 | 0.125 | 1 | 1 |
| CDC 197 | 4 | 2 | 4 | 2 |
| CDC 202 | 4 | 2 | 4 | 16 |
| CDC 211 | 1 | 2 | 4 | 1 |
| ATCC 700825 | 0.5 | 0.5 | 0.5 | 0.25 |
| MS11 | 0.5 | 0.125 | 1 | 0.25 |
| WHO-K | 1 | 0.25 | 1 | 0.25 |
| WHO-X | 1 | 0.25 | 1 | 0.25 |
| WHO-W | 2 | 0.25 | 1 | 0.125 |
| aMIC50 | 2 | 0.5 | 2 | 2 |
| bMIC90 | 4 | 2 | 4 | 4 |
AZI = azithromycin, AZM = acetazolamide.
a
MIC50: minimum inhibitory concentration at which the compound/drug inhibited 50% of the tested strains.
b
MIC90: minimum inhibitory concentration at which the compound/drug inhibited 90% of the tested strains.