Skip to main content
. Author manuscript; available in PMC: 2021 Jul 28.
Published in final edited form as: J Med Chem. 2020 Aug 11;63(17):9540–9562. doi: 10.1021/acs.jmedchem.0c00734

Table 1.

Minimum inhibitory concentrations (MICs) for AZM-based analogs against E. faecium HM-965

graphic file with name nihms-1722043-t0015.jpg

Compound R MICa Compound R MICa

AZM graphic file with name nihms-1722043-t0016.jpg 2 17 graphic file with name nihms-1722043-t0017.jpg 0.25
3 graphic file with name nihms-1722043-t0018.jpg 1 18 graphic file with name nihms-1722043-t0019.jpg 0.25
4 graphic file with name nihms-1722043-t0020.jpg 1 19 graphic file with name nihms-1722043-t0021.jpg 0.06
5 graphic file with name nihms-1722043-t0022.jpg 0.25 20 graphic file with name nihms-1722043-t0023.jpg 0.06
6 graphic file with name nihms-1722043-t0024.jpg 0.5 21 graphic file with name nihms-1722043-t0025.jpg 0.06
7 graphic file with name nihms-1722043-t0026.jpg 0.125 22 graphic file with name nihms-1722043-t0027.jpg 0.007
8 graphic file with name nihms-1722043-t0028.jpg 0.015 23 graphic file with name nihms-1722043-t0029.jpg 0.06
9 graphic file with name nihms-1722043-t0030.jpg 0.015 24 graphic file with name nihms-1722043-t0031.jpg 1
10 graphic file with name nihms-1722043-t0032.jpg 2 25 graphic file with name nihms-1722043-t0033.jpg 1
11 graphic file with name nihms-1722043-t0034.jpg 0.5 26 graphic file with name nihms-1722043-t0035.jpg 1
12 graphic file with name nihms-1722043-t0036.jpg 0.25 27 graphic file with name nihms-1722043-t0037.jpg 8
13 graphic file with name nihms-1722043-t0038.jpg 0.25 28 graphic file with name nihms-1722043-t0039.jpg 2
14 graphic file with name nihms-1722043-t0040.jpg 0.25 29 graphic file with name nihms-1722043-t0041.jpg > 64
15 graphic file with name nihms-1722043-t0042.jpg 0.25 30 graphic file with name nihms-1722043-t0043.jpg > 64
16 graphic file with name nihms-1722043-t0044.jpg 2 31 graphic file with name nihms-1722043-t0045.jpg > 64

AZM = acetazolamide.

a

MIC values in μg/mL against E. faecium strain HM-965