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. Author manuscript; available in PMC: 2021 Jul 28.
Published in final edited form as: J Med Chem. 2020 Aug 11;63(17):9540–9562. doi: 10.1021/acs.jmedchem.0c00734

Table 5.

Experimental pharmacokinetic indices for analog 22

Animal-Dose Tmax (h)b Cmax (ng/ml)c AUCinf (h*ng/mL)d AUC/D (h*kg*ng/mL/mg)e MRT (h)f
PO-Mousea 0.50 456 ± 21 562 56 1.35
a

Dosed by oral gavage to mice.

b

Tmax = time-point of maximum plasma concentration.

c

Cmax = maximum plasma concentration.

d

AUCinf = area under the curve extrapolated to timepoint infinity.

e

AUC/D = area under the curve divided by dose.

f

MRT = mean residence time.