Structure–Activity Relationship of Heterocyclic P2Y14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres

. Author manuscript; available in PMC: 2022 Apr 22.

Published in final edited form as: J Med Chem. 2021 Mar 31;64(8):5099–5122. doi: 10.1021/acs.jmedchem.1c00164

Chart 1. Structure of Reported P2Y14R Antagonist Ligands, Including High Affinity Fluorescent Conjugate 2 Used to Determine Receptor Affinity in a Whole Cell Flow Cytometry Assaya.