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. 2021 Jun 21;61(7):3722–3733. doi: 10.1021/acs.jcim.1c00293

Figure 4.

Figure 4

hERG regression results for all valid models. Efficiency is expressed in terms of prediction interval width at a fixed confidence of 0.8; smaller values are preferable. The colored areas correspond to the 95% CI computed from the ten replicate runs. The overall winning strategy is the CCPAT, having overlapping CIs for the smaller Anew sizes but favorable when more data is used from Anew. The results are more prominent in the second row of panels, where more Aold observations are used.