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. 2021 Jul 14;12:639019. doi: 10.3389/fimmu.2021.639019

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Copyright © 2021 Zhou, Li, Gao, Yuan, Zuo, Wu, Huang and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SpvC phosphothreonine lyase activity is critical for inhibiting autophagy in Salmonella Typhimurium infection. (A, B) J774A.1 cells were infected with STM-WT, STM-ΔspvC, STM-ΔspvC/pspvC or STM-ΔspvC/pspvC K136A at an MOI of 10 for 2 h. Cell lysates were analysed by western blot with specific antibodies to LC3 (A), Beclin 1 (B) and the control GAPDH. (C) HeLa cells were infected with STM-WT, STM-ΔspvC or STM-ΔspvC/pspvC at an MOI of 100 after being pretreated with PD0325901. Cell lysates were analysed by western blot with specific antibodies to LC3, Beclin 1 and the control Actin at 0.5 hpi, 2 hpi and 6 hpi. Data were compared by ANOVA. Values are expressed as the means ± S.D., n = 3. Statistically significant differences are indicated. ***P < 0.001; *P < 0.01; ns, not significant.