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Plot of vitreal half-life as a function of (A) Log P, (B) Molecular weight, and (C), Dose number (Dose/Solubility at pH 7.4) for about 68 drugs. Vitreal half-life, MW, and Dose Number are shown in logarithmic scale. Reprinted with permission from Durairaj et al., 2008. Copyright 2008, Springer Science Business Media, LLC, part of Springer Nature.
